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. 2019 Aug 16;10:892. doi: 10.3389/fphar.2019.00892

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Copyright © 2019 Jang, Lee, Park, Kim, Shim, Lee, Han, Myung, Kim, Jang, Lee and Myung

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baicalein attenuates endothelial dysfunction in radiation-induced intestinal injury. mRNA levels of (A) P-selectin, (B) ICAM-1, and (C) VCAM-1 in control (Con), baicalein treated (Bai), irradiated (IR), and baicalein-treated IR (IR+Bai) HUVECs, as determined by real-time RT-PCR. n = 3 per group. (D) Immunohistochemical analysis of P-selectin and mRNA levels of (E) P-selectin, (F) Icam-1, and (G) Vcam-1 in the intestine of Con, IR, and IR+Bai mice. Arrowhead indicates P-selectin-positive endothelial cell. Bar = 100 μm. Data are presented as the mean ± standard error of the mean; n = 5 mice for each group. *P < 0.05 compared to the control; ^# P < 0.05 compared to the IR group.