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. 2019 Aug 16;10:892. doi: 10.3389/fphar.2019.00892

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Copyright © 2019 Jang, Lee, Park, Kim, Shim, Lee, Han, Myung, Kim, Jang, Lee and Myung

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baicalein inhibits the inflammatory response during radiation-induced enteropathy. Protein expression of (A) interleukin (IL)-33, (B) matrix metalloproteinase-9 (MMP-9), and (C) IL-1β in the intestine of control (Con), irradiated (IR), and baicalein-treated IR (IR+Bai) mice. Immunostaining of (D) IL-6 and (E) CD4 in the intestine of Con, IR, and IR+Bai mice. mRNA levels of (F) Il-33, (G) Mmp-9, (H) Il-6, (I) Il-1β, (J) Cd4, and (K) Il-13 in the intestine of Con, IR, and IR+Bai mice. Red arrow indicates IL-6 positive cell and white arrow indicated CD4 positive cell. Bar = 100 μm. Data are presented as the mean ± standard error of the mean; n = 5 mice for each group. *P < 0.05 compared to the control; ^# P < 0.05 compared to the IR group.