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. 2019 Aug 16;10:892. doi: 10.3389/fphar.2019.00892

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Copyright © 2019 Jang, Lee, Park, Kim, Shim, Lee, Han, Myung, Kim, Jang, Lee and Myung

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baicalein improves crypt regeneration in radiation-induced enteritis. (A) Immunohistochemistry of Ki-67 in the intestine of control (Con), irradiated (IR), and baicalein-treated IR (IR+Bai) mice at 6 days after irradiation. Red arrow indicates Ki-67 positive cells. (B) Representative morphology of isolated intestinal crypts in Con, IR, and IR+Bai mice at 6 days after irradiation. Red arrow indicates crypts. (C) Enteroid formation assay cultured in vitro for 7 days and (D) percentage of budding organoids in Con, IR, and IR+Bai groups. Data are presented as the mean ± standard error of the mean; n = 3 samples for each group. *P < 0.05 compared to the control; ^# P < 0.05 compared to the IR group.