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. 2019 Aug 16;10:893. doi: 10.3389/fphar.2019.00893

Table 1.

List of studies involving the treatment of different species with propranolol.

Species Study Endpoint* Control sample size Treatment sample size Health status of the experimental subjects
Human Bellissant et al., 1994 HR, BF, VD, SV 6–7 6–7 Healthy
Human Crawford et al., 1980 HR 10–19 10–19 Healthy
Human Danesh et al., 1984 BF 7 7 Disease
Human Le Winter et al., 1975 HR 10 10 Healthy
Human Marshall et al., 1981 HR 7 18 Healthy/disease
Human Mo et al., 2011 HR 126 126 Healthy/disease
Human Morris et al., 1983 HR 22 22 Disease
Human Port et al., 1980 HR, SV 12 12 Healthy
Human Saigal et al., 1998 HR, BF, VD 10 10 Disease
Human Zain-Hamid et al., 2003 HR, BF, VD 12 4 Disease
Dog Berdeaux et al., 1991 HR, BF, VD 7 7 Healthy
Dog Driscoll et al., 1982 HR, BF, SV 9–10 9–10 Healthy
Dog Kuhn et al., 1990 BF, VD, SV 6 6 Healthy
Dog Vigue et al., 1993 HR, BF, VD 6 6 Healthy
Dog Willems et al., 1986 HR, BF 8 8 Disease
Rat Chillon and Baumbach, 1999 VD 16 13 Disease
Rat Gay et al., 1990 HR, SV 12 10 Healthy/Disease
Rat Hatzinikolaou et al., 1983 HR, SV 7 7 Healthy
Rat Rochette et al., 1987 HR, BF, SV 6 6 Healthy
Rat Skinner et al., 1996 HR, BF 5–9 7–9 Healthy/disease
Zebrafish Finn et al., 2012 HR 20 20 Healthy
Zebrafish Fraysse et al., 2006 HR 48 48 Healthy
Zebrafish Schwerte et al., 2006 HR 7 7 Healthy
Zebrafish Present study HR, BF, VD, SV 4–6 4–6 Healthy

*HR, #Heart rate; BF, Blood flow; VD, Vessel diameter; SV, Stroke volume.