Table 1.
Species | Study | Endpoint* | Control sample size | Treatment sample size | Health status of the experimental subjects |
---|---|---|---|---|---|
Human | Bellissant et al., 1994 | HR, BF, VD, SV | 6–7 | 6–7 | Healthy |
Human | Crawford et al., 1980 | HR | 10–19 | 10–19 | Healthy |
Human | Danesh et al., 1984 | BF | 7 | 7 | Disease |
Human | Le Winter et al., 1975 | HR | 10 | 10 | Healthy |
Human | Marshall et al., 1981 | HR | 7 | 18 | Healthy/disease |
Human | Mo et al., 2011 | HR | 126 | 126 | Healthy/disease |
Human | Morris et al., 1983 | HR | 22 | 22 | Disease |
Human | Port et al., 1980 | HR, SV | 12 | 12 | Healthy |
Human | Saigal et al., 1998 | HR, BF, VD | 10 | 10 | Disease |
Human | Zain-Hamid et al., 2003 | HR, BF, VD | 12 | 4 | Disease |
Dog | Berdeaux et al., 1991 | HR, BF, VD | 7 | 7 | Healthy |
Dog | Driscoll et al., 1982 | HR, BF, SV | 9–10 | 9–10 | Healthy |
Dog | Kuhn et al., 1990 | BF, VD, SV | 6 | 6 | Healthy |
Dog | Vigue et al., 1993 | HR, BF, VD | 6 | 6 | Healthy |
Dog | Willems et al., 1986 | HR, BF | 8 | 8 | Disease |
Rat | Chillon and Baumbach, 1999 | VD | 16 | 13 | Disease |
Rat | Gay et al., 1990 | HR, SV | 12 | 10 | Healthy/Disease |
Rat | Hatzinikolaou et al., 1983 | HR, SV | 7 | 7 | Healthy |
Rat | Rochette et al., 1987 | HR, BF, SV | 6 | 6 | Healthy |
Rat | Skinner et al., 1996 | HR, BF | 5–9 | 7–9 | Healthy/disease |
Zebrafish | Finn et al., 2012 | HR | 20 | 20 | Healthy |
Zebrafish | Fraysse et al., 2006 | HR | 48 | 48 | Healthy |
Zebrafish | Schwerte et al., 2006 | HR | 7 | 7 | Healthy |
Zebrafish | Present study | HR, BF, VD, SV | 4–6 | 4–6 | Healthy |
*HR, #Heart rate; BF, Blood flow; VD, Vessel diameter; SV, Stroke volume.