Table 3.

List of studies involving the treatment of different species with captopril.

Species	Study	Endpoint*	Control sample size	Treatment sample size	Health status of the experimental subjects
Human	Aznaouridis et al., 2007	VD	25	25	Disease
Human	Burggraaf et al., 1998	HR, BF	9	9	Healthy
Human	Chau et al., 1992	VD	8	8	Disease
Human	Cleland et al., 1991	HR	16	16	Disease
Human	Leier et al., 1983	SV	7	7	Disease
Human	Massie et al., 1982	HR, SV	14	14	Disease
Human	Sturani et al., 1982	HR	15	15	Disease
Human	Vandenburg et al., 1983	HR	9	9	Disease
Human	Konstam et al., 2000	HR	16	16	Disease
Human	Schreij et al., 1996	BF	8–50	8–50	Disease
Human	Van den Broek et al., 1995	BF	9	9	Disease
Human	Schanzenbacher and Liebau, 1983	SV	9	9	Disease
Dog	Blackford et al., 1990	SV	10	5	Disease
Dog	Jugdutt, 1995	HR	12	12	Disease
Dog	Lynch et al., 1999	HR	9	10	Disease
Dog	Satoh et al., 1980	BF	8	8	Healthy
Dog	Shannon et al., 1997	HR, BF	5–9	5–9	Disease
Dog	Wong et al., 1981	BF	9	9	Disease
Dog	Zimmerman et al., 1982	BF	6	6	Disease
Rat	Silva et al., 2002	HR	10	7–10	Healthy
Rat	Freslon and Giudicelli, 1983	VD	10	10	Disease
Rat	Jin et al., 2001	HR	6	6	Disease
Rat	Kimura et al., 1991	VD	5–6	5	Disease
Rat	Koike et al., 1980	BF	7	6–7	Disease
Rat	Miguel-Carrasco et al., 2010	HR	6	6	Healthy
Rat	Pfeffer et al., 1982	SV	11–13	9	Healthy/disease
Rat	Pfeffer et al., 1985	SV	8–36	8–23	Healthy/disease
Rat	Raya et al., 1989	HR	9	7	Disease
Rat	Rozsa and Sonkodi, 1995	BF	10	10	Healthy/disease
Rat	Skinner et al., 1996	HR, BF	6–14	6	Healthy/disease
Rat	Wang and Prewitt, 1991	VD	9–11	9–11	Healthy
Zebrafish	Present study	HR, BF, VD, SV	4–6	4–6	Healthy

*HR, Heart rate; BF, Blood flow; VD, Vessel diameter; SV, Stroke volume.