Table 1.
Descriptive statistics for traits used in the quantitative genetic analyses
| Mean | SD | Range | Correlation with BMI | ||
|---|---|---|---|---|---|
| BMI (kg/m2), n = 1,635 | 31.6 | 7.4 | 63 | ρ p (p) | ρ g (p) |
| Inflammatory markers (p g/mL), n = 1,817 | |||||
| IL‐6 | 3.86 | 16.70 | 588.89 | 0.27 (8.8 × 10−26)* | 0.41 (.002)* |
| IL‐8 | 3.34 | 5.06 | 98.32 | −0.03 (0.27) | 0.03 (.78) |
| TNFα | 2.51 | 1.92 | 23.22 | 0.13 (1.4 × 10−06)* | 0.05 (.64) |
| DTI measures (FA), n = 1,320 | |||||
| Whole skeleton | 0.46 | 0.03 | 0.26 | −0.05 (0.14) | −0.19 (.03) |
| Anterior thalamic radiation (ATR) | 0.50 | 0.04 | 0.34 | −0.02 (0.56) | −0.21 (.05) |
| Cingulum bundle (CgC) | 0.61 | 0.05 | 0.33 | 0.003 (0.92) | −0.13 (.17) |
| Cingulum hippocampal part (CgH) | 0.45 | 0.06 | 0.60 | 0.19 (5.4 × 10−09)* | 0.01 (.94) |
| Corticospinal tract (CST) | 0.62 | 0.04 | 0.49 | 0.02 (0.54) | −0.10 (.27) |
| Forceps major (FMa) | 0.68 | 0.05 | 0.38 | −0.06 (0.07) | −0.21 (.02) |
| Forceps minor (FMi) | 0.57 | 0.05 | 0.35 | −0.09 (0.006)* | −0.17 (.06) |
| Inferior fronto‐occipital fasciculus (IFOF) | 0.53 | 0.04 | 0.33 | −0.07 (0.03) | −0.25 (.01) |
| Inferior longitudinal fasciculus (ILF) | 0.51 | 0.03 | 0.35 | −0.02 (0.53) | −0.24 (.01) |
| Superior longitudinal fasciculus (SLF) | 0.51 | 0.04 | 0.28 | −0.08 (0.009)* | −0.23 (.01) |
| Superior longitudinal fasciculus temporal part (tSLF) | 0.58 | 0.04 | 0.37 | −0.01 (0.79) | −0.11 (.29) |
| Uncinate fasciculus (UF) | 0.52 | 0.05 | 0.41 | −0.002 (0.95) | −0.13 (.21) |
Note: Inflammatory markers are serum‐based measures of IL‐6, IL‐8, and TNFα. DTI measures are bilateral FA values obtained from averaging the right and left hemispheres (excluding the forceps major and minor) of tracts in the JHU white matter atlas. Table shows mean, standard deviation, and range for each measure included in the quantitative genetic analyses. Genetic correlation analyses were used to estimate the phenotypic and genetic correlations between each measure and BMI. Reported p‐values are uncorrected (FDR corrected p‐values are listed in Table S1).
*
Significant correlation with BMI, FDR corrected p < .05.