Table 2.

The absolute risk, odds ratio (OR) and adjusted OR^* for metachronous advanced adenomas in individuals with index adenomas as classified by current guideline categories, stratified by adenoma size

Index findings	N	Absolute risk (%) (95% Cl)	Unadjusted OR (95% Cl)	*Adjusted OR (95% Cl)	P value
1–2 diminutive adenomas	2568	4.0 (3.2–4.8) (n=103)	Reference (1.0)	1.0 Reference	…
1–2 adenomas < 1cm** (one or more small)	1294	5.9 (4.7–7.3) (n=76)	1.49 (1.10–2.02)	1.54 (1.12–2.11)	0.008
3–10 diminutive adenomas	293	8.2(5.4–11.9) (n=24)	2.14(1.35–3.39)	1.75(1.03–2.95)	0.03
3–10 adenomas < 1cm (one or more small)	425	9.4(6.4–11.9) (n=40)	2.49(1.70–3.64)	2.14(1.39–3.29)	0.001
Advanced adenoma***	1503	10.0(9.2–12.2) (n=150)	2.65 (2.05–3.44)	2.77 (2.05–3.74)	0.0001

^*Adjusted for age, sex, BMI, family history of CRC, smoking, presence or serrated polyps and years since index exam.

^**Subset of Group 2 of adults with 2 small adenomas (versus 1 or more small) absolute risk: 7.3% (95% CI; 5.0–10.4%)

^***Advanced adenomas: adenomas ≥1cm or those with villous elements, high-grade dysplasia, or CRC.