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. Author manuscript; available in PMC: 2019 Nov 27.
Published in final edited form as: Nat Microbiol. 2019 May 27;4(9):1486–1496. doi: 10.1038/s41564-019-0461-2

Figure 5|. Strain-transcending human mAbs overcome polymorphisms located within the vicinity of their epitopes.

Figure 5|

a, Location of polymorphisms R263S and N372K on DBP-II surface shown in DBP-II/053054 and DBP-II/092096 structures. Polymorphic residues 263 and 372 shown in ball representation in yellow and green, respectively. The location of R263 was modeled as this residue is located in a disordered segment that is not visible in either structure. b, ELISA for 053054 and 092096 against Sal-I DBP-II wild type and three DBP-II natural variants, R263S, N372K and double mutant R263S/N372K. Data are shown as mean ± SD, calculated from three independent experiments. Statistical differences between wild type Sal-1 DBP and the mutants were analyzed by one-way ANOVA and Dunnett’s test (****p < 0.0001).