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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: Mol Cell. 2019 Jul 9;75(4):781–790.e3. doi: 10.1016/j.molcel.2019.06.007

Figure 4. Comparisons of ICL2 in the Rho-GT-Nb35* complex and other GPCR complexes.

Figure 4.

(A) Conformation of ICL2 in GT-bound Rho and its interactions with eGαT in the Rho-GT-Nb35* complex (GT-bound Rho in strawberry, GαT in lime). (B) Conformation of ICL2 in β2AR and its interactions with GαS in the β2AR-GS complex (PDB: 3SN6) (β2AR in salmon, GαS in green). (C) Conformation of ICL2 in μOR and its interactions with Gαi in the μOR-Gi complex (PDB: 6DDF) (μOR in orange, Gαi in grey). (D) Conformation of ICL2 in arrestin-bound Rho and its interactions with arrestin in the Rho-arrestin complex (PDB: 4ZWJ) (arrestin-bound Rho in purple, arrestin in teal).

See also Figure S6.