Table 2.

The association of insulin resistance on MWF in brain regions

Region	Coordinates (millimeters)	T-Value	Observed extent threshold	Cluster level p-value
IR positive direction cluster data (n=126)
Right superior precentral region	54, 14, 30	4.29	1027	.001
Right superior temporo-parietal region	28, −102, 0	4.24	1185	.000
Right inferior temporal region	34, 12, −42	4.11	892	.001
Right superior temporo-parietal region	50, −58, 26	4.03	621	.005
Left occipito-parietal region	−22, −106, 0	4.00	509	.009
Left inferior middle region	−40, −68, 2	3.81	427	.015
Left superior temporal region	−56, −60, 22	3.74	286	.040
Right middle superior frontal region	32, 20, 58	3.73	294	.038
Left superior medial-frontal region	−52, −2, 46	3.54	405	.017
Right superior temporal region	68, −8, −2	3.60	640	.004
Right superior frontal region	24, 62, −6	3.57	398	.018
IR negative direction cluster data (n=126)
Parieto-occipital projections of corpus callosum	−10, −84, 14	4.80	3801	.000
Cuneus White Matter	10, −76, 14	4.22	657	.004

Extent threshold (k) = 174 voxels, p<.005, uncorrected for positive and negative directional multiple regression analyses. All significant voxel-level p-values were less than .005.

Abbreviations: MWF = myelin water fraction; IR = insulin resistance.