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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: J Pediatr Surg. 2019 Feb 23;54(11):2402–2407. doi: 10.1016/j.jpedsurg.2019.02.021

Fig 4. Paneth cell disruption with dithizone results in a significant decrease in small intestine mRNA expression of NOS genes.

Fig 4.

(A) Dithizone treated mice had significantly decreased mRNA expression of nNOS (p<0.01) and (B) significantly decreased mRNA expression of iNOS compared to controls (p<0.01). (C) Dithizone treated mice had a trend towards decreased eNOS expression but significance was not quite reached (p=0.10). Diphtheria toxin treated mice had no significant difference in any NOS gene expression compared to controls. (D) Immunohistochemical staining for eNOS (brown) in the small intestine from control and dithizone treated mice showed decreased eNOS staining in the dithizone treated group. Scale bar equals 50μm.