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Working model. This figure is a comparison of the two different curli preparations used throughout our experiments as well as the difference involved in their processing. High-turbulence growth conditions produced smaller curli intermediates, which incorporate less DNA and are cytotoxic to murine macrophages. Alternatively, low-turbulence growth conditions led to larger fibrillar aggregates, which incorporate more DNA and are not cytotoxic to murine macrophages.
