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. 2019 Aug 19;13:2899–2909. doi: 10.2147/DDDT.S212500

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© 2019 Luan and Chen.

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Structure of human IgG1 antibody and carbohydrate of glycoengineered antibody. (A) The mAbs of human IgG1 isotype consist of two immunoglobulin light chains and two immunoglobulin heavy chains. Heavy chains are covalently paired by disulﬁde bonds in hinge regions, and each heavy chain is connected to a light chain by a disulﬁde bond between CH1 and CL. A pair of VH and VL in Fab regions makes an antigen-binding site. In the CH2 domains of Fc regions, an oligosaccharide is covalently attached to the both domains at asparagine 297 (Asn-297). (B) Scheme of the glycoengineered bisected carbohydrate chain of a glycoengineered antibody.