Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison between Type I CD20 mAb and Type II CD20 mAb
| Type Ⅰ CD antibodies | Type Ⅱ CD antibodies | |
|---|---|---|
| ADCC | moderate | strong |
| ADCP | moderate | strong |
| CDC | strong | weak |
| DCC | weak | strong |
| Homotypic cell aggregation | weak/no | strong |
| CD20 accumulation in lipid rafts | Yes | No |
| CD20 binding capacity | Full | Half maximal |
| Glyco-engineered | No | Yes |
Abbreviations: ADCC, antibody-dependent cellar cytotoxicity; ADCP, antibody-dependent cellar phagocytosis; CDC, complement-dependent cytotoxicity; DCC, direct cell death.
