. 2019 Aug 19;12:6665–6684. doi: 10.2147/OTT.S207963

Table 2.

Diagnostic performance of miRNA panels in pancreatic cancer

Study	County	Cases vs Controls			Specimen	Stage	miRNA	SEN	SPE	AUC
Number	Age(y)	Male (%)
Franklin, 2018a²¹	Sweden	23/22	64/62	52/55	Plasma	I-II	Panel A	/	/	0.96
Duell, 2017b²⁰	Europe^c	29/29	/	/	Plasma	/	Panel B	/	/	0.73
Johansen, 2016³⁴	Denmark	86/44	67/55	57/50	Serum	I-IV	Panel C	85	67	0.84
	Panel D	85	71	0.72
	Denmark, Germany	153/247	/	/	Serum	I-II	Panel E	86	68	0.83
							Panel F	83	73	0.86
							Panel C	82	60	0.77
							Panel D	86	73	0.87
	Denmark, Germany	11/247	/	/	Serum	I	Panel E	73	68	0.70
							Panel F	55	73	0.76
							Panel C	82	60	0.74
							Panel D	64	73	0.78
	Denmark, Germany	142/247	/	/	Serum	II	Panel E	87	68	0.84
							Panel F	85	73	0.87
							Panel C	82	60	0.77
						Panel D	88	73	0.88
Alemar, 2016³⁶	Brazil	24/10	62/NA	50/NA	Serum	I-IV	−21, −34a	/	/	0.89
Slater, 2014⁴¹	Germany	9/10	/	/	Serum	I-IV	−196b, −196a	100	100	1.00
Lin, 2014⁴²	China	49/27	62/61	55/56	Serum	I-IV	−663a, −492	86	80	0.87
Ganepola, 2014⁴³	USA	11/11	68/46	54/54	Plasma	II	Panel G	91	91	0.97
Liu, R, 2012⁴⁶	China	95/81	/	/	Serum	I-IV	Panel H	94	93	0.99
Liu, J, 2012⁴⁷	China	138/68	62/61	64/66	Plasma	I-IV	−16, −196a	87	74	0.90
Wang, 2009⁴⁸	USA	28/19	/	/	Plasma	/	Panel I	64	89	0.82

Notes: ^aRepresents the study concluded prospective and cross-sectional study and the data extracted from the part of cross-sectional study; ^brepresents the incidence of Pancreatic Cancer by follow-up 5 years); ^c10 European countries including Denmark (Aarhus, Copenhagen), France, Germany (Heidelberg, Potsdam), Greece, Italy (Florence, Turin, Varese, Naples, Ragusa), The Netherlands (Bilthoven, Utrecht), Norway, Spain (Asturias, Granada, Murcia, Navarra, Guipuzcoa), Sweden (Malmo, Umeå) and the United Kingdom (Oxford, Cambridge); SENs, SPEs, and AUCs in bold fonts represent results from validation set (non-bold fonts represent results without validation). Panel A (15 miRs): −106b, −574, −34a, −451a, −130b, −26a, −144, −423, −101, −122,-24, −22-5p, let-7d-3p, −197, −885-5p; Panel B: −10a, −10b, −21, −30c, −106b, −155, −212; Panel C: −16, −27a, −25, −29c, −483-5p; Panel D (12 miRs): −16, −18a, −24, −27a, −30a, −323, −20a, −25, −29c,-191, −345, −483-5p; Panel E: −16, −27a, −30a, −323, −20a, −29c, −483-5p; Panel F: −16, −24, −27a, −30a, −323, −20a, −25, −29c, −483-5p; Panel G: −22, −642b, −885-5p; Panel H: −20a, −21, −24, −25, −99a, −185, −191; Panel I: −21, −210, −155, 196a.

Abbreviations: SEN, sensitivity; SPE, specificity; AUC, area under the curve; NA: not available.