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. 2019 Aug 20;10(49):5028–5040. doi: 10.18632/oncotarget.27096

Figure 1. Low CTNNA2 expression is associated with disease relapse and mortality in patients with neuroblastoma lacking MYCN amplification.

Figure 1

We analyzed the expressions of three CTNNA members in two datasets by utilizing the R2 analysis and visualization platform (http://r2.amc.nl). (A) The expression levels of CTNNA1 and CTNNA2 were higher than CTNNA3 in Wolf’s dataset which is a gene expression profiles generated from 498 primary neuroblastomas using RNA-Seq and microarrays. (B) The similar result showed in Seeger’s dataset which is a gene expression profiles of primary tumors from 102 patients with metastatic neuroblastoma lacking MYCN amplification. (C) CTNNA1 expression was analyzed in the overall of Wolf’s dataset using Kaplan scan. Kaplan–Meier curves showed the lower probability of relapse-free survival associated with lower expression of CTNNA1 (D) CTNNA1 expression was analyzed in MYCN-amplified subgroup of Wolf’s dataset using Kaplan scan. No significant relation between a probability of relapse-free survival and CTNNA1 expression (E) CTNNA1 expression was analyzed in non-MYCN-amplified subgroup of Wolf’s dataset using Kaplan scan. Kaplan–Meier curves showed the lower probability of relapse-free survival associated with lower expression of CTNNA1 (F) CTNNA2 expression was analyzed in the overall of Wolf’s dataset using Kaplan scan. Kaplan–Meier curves showed the lower probability of relapse-free survival associated with lower expression of CTNNA2 (G) CTNNA2 expression was analyzed in MYCN-amplified subgroup of Wolf’s dataset using Kaplan scan. No significant relation between a probability of relapse-free survival and CTNNA2 expression (H) CTNNA2 expression was analyzed in non MYCN-amplified subgroup of Wolf’s dataset using Kaplan scan. Kaplan–Meier curves showed the lower probability of relapse-free survival associated with lower expression of CTNNA2 (I) CTNNA1 expression was analyzed in Seeger’s dataset using Kaplan scan. Kaplan–Meier curves showed the lower probability of relapse-free survival associated with lower expression of CTNNA1 (J) CTNNA2 expression was analyzed in Seeger’s dataset using Kaplan scan. Kaplan–Meier curves showed the lower probability of relapse-free survival associated with lower expression of CTNNA2.