Table 5. Overlap of SS DEGs, L-HES DEGs, and shared DEGs with MSigDB Hallmark gene sets.
| Hallmark biological process | Shared DEGs | SS DEGs | L-HES DEGs | ||
|---|---|---|---|---|---|
| Up | Down | Up | Down | ||
| IL-2 STAT5 Signaling | 8.66E-13 | 5.39E-04 | 6.59E-19 | 5.13E-07 | 4E-14 |
| Apoptosis | 1.70E-07 | n.s. | 2.47E-07 | 3.78E-06 | 6.97E-06 |
| Complement | 7.78E-06 | n.s. | 3.76E-12 | 1.8E-02 | 1.46E-08 |
| Inflammatory Response | 7.78E-06 | 3.26E-02 | 3.34E-09 | 1.14E-04 | 1.46E-08 |
| Allograft Rejection | 6.39E-05 | n.s. | 4.07E-13 | 2.86E-06 | 2.59E-09 |
| Interferon Gamma Response | 6.39E-05 | n.s. | 3.34E-09 | 1.66E-05 | 2.59E-09 |
| TGFβ Signaling | 2.93E-04 | 7.58E-03 | 1.53E-05 | n.s. | 3.51E-03 |
| KRAS Signaling Up | 4.56E-04 | 7.76E-03 | 2.89E-08 | n.s. | 4.51E-03 |
| TNFα Signaling via NF-κB | 4.56E-04 | n.s. | 3.34E-09 | 1.66E-05 | 4.28E-11 |
| IL-6 JAK STAT3 Signaling | 1.32E-03 | 3.44E-03 | 1.01E-02 | 5.97E-05 | n.s. |
The top ten Hallmark gene sets that showed significant overlap with the 163 DEGs shared between SS and L-HES are listed. MSigDB overlap FDR q-values ≤ 0.05 are compared between groups of DEGs (n.s., not significant). SS DEG and L-HES DEG categories include all up- or downregulated genes exceeding log2FC ≥ |1| and RankProd pfp≤ 0.05.