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. 2019 Aug 20;10(49):5092–5102. doi: 10.18632/oncotarget.27149

Figure 3. Neurotensin potentiates the effect of EGF on DNA replication and cell proliferation.

Figure 3

(A) Percent of AML12 cells staining for BrdU after no treatment, EGF, the NTS analog JMV 449, or EGF + JMV. * p < 0.05. (B) AML12 cell proliferation in AML 12 cells with no treatment, EGF, JMV 449m or EGF + JMV, as measured by the MTS assay. *denotes p < 0.05 compared to untreated AML12 cells. Proliferation of Huh7 cells (C) or HepG2 cells (D) after treatment with EGF, JMV449, or both, as measured by the MTS assay. (E) Neurotensin increases cell proliferation in FL-HCC slice cultures as measured by the MTS assay. F. PKA inhibition with H89 does not affect JMV/EGF-induced proliferation of AML12 cells, as measured by the MTS assay.