Table 2.
Comparison of IVF/ICSI treatment cycle outcomes between women with endometriosis versus controls. Data are mean or percent (95% CI)
| Women with endometriosis (treatments n = 297) |
Control Women (treatments n = 4301) | p value | p value (adjusted for IVF/ICSI and agonist/antagonist) | |
|---|---|---|---|---|
| Days of gonadotropin stimulation | 10.85 (10.65–11.04) | 10.47 (10.40–10.53) | 0.0010 | 0.68 |
| FSH total dose (IU)/OPU | 2828 (2664–2992) | 2370 (2328–2412) | < 0.0001 | 0.11 |
| Oocytes (total number retrieved at OPU) | 8.47 (7.86–9.08) | 9.54 (9.37–9.71) | 0.0040 | 0.0146 |
| Ovarian sensitivity index | 4.17 (3.75–4.60) | 5.74 (5.59–5.90) | < 0.0001 | 0.0002 |
| Embryos obtained | 4.35 (3.90–4.81) | 4.32 (4.19–4.46) | 0.91 | 0.35 |
| Embryoscore (1–10) day 2 | 9.50 (9.34–9.67) | 9.41 (9.36–9.46) | 0.29 | 0.33 |
| Frozen embryos | 2.24 (1.95–2.53) | 2.51 (2.42–2.61) | 0.13 | 0.11 |
| Embryos to ET (fresh) | 1.28 (1.22–1.34) | 1.24 (1.23–1.26) | 0.27 | 0.50 |
| Embryos to ET (thaw) | 1.10 (1.05–1.16) | 1.08 (1.07–1.10) | 0.49 | 0.50 |
| SET (%) | 71.98 (66.46–77.51) | 75.62 (74.22–77.03) | 0.25 | 0.48 |
| Canceled cycles (no OPU or no ET) (%) | 13.47 (9.56–17.37) | 16.23 (15.13–17.33) | 0.22 | 0.59 |
| Clinical pregnancy/stimulation start (%) | 30.98 (25.69–36.27) | 28.95 (27.59–30.30) | 0.47 | 0.73 |
| Clinical pregnancy/OPU (%) | 32.39 (26.92–37.87) | 31.06 (29.62–32.49) | 0.65 | 0.73 |
| Clinical pregnancy/ET (%) | 35.80 (29.90–41.70) | 34.55 (33.00–36.11) | 0.70 | 0.81 |
| Clinical pregnancy/ET Thaws (%) | 26.19 (18.41–33.97) | 31.59 (29.52–33.67) | 0.26 | – |
| Cumulative clinical pregnancy/OPU (fresh and frozen ET) (%) | 42.61 (36.82–48.39) | 40.41 (38.89–41.93) | 0.48 | 0.60 |
| Cumulative clinical pregnancy/ET (fresh and frozen ET) (%) | 47.08 (40.94–53.23) | 44.24 (42.62–45.86) | 0.40 | 0.54 |
| LBRs/stimulation start (%) | 25.25 (20.28–30.22) | 23.79 (22.51–25.06) | 0.57 | 0.78 |
| LBRs/OPU (%) | 26.41 (21.25–31.57) | 25.52 (24.17–26.87) | 0.75 | 0.78 |
| LBRs/ET (%) | 29.18 (23.59–34.78) | 28.39 (26.92–29.87) | 0.79 | 0.85 |
| LBRs/ET thaws (%) | 22.22 (14.86–29.58) | 26.16 (24.20–28.12) | 0.37 | – |
| Cumulative LBRs/OPU (fresh and frozen ET) (%) | 35.56 (29.96–41.16) | 34.67 (33.20–36.15) | 0.76 | 0.83 |
| Cumulative LBRs/ET (fresh and frozen ET) (%) | 39.30 (33.29–45.31) | 37.89 (36.30–39.47) | 0.66 | 0.76 |
| Miscarriages (%) | 18.48 (10.40–26.56) | 17.83 (15.70–19.96) | 0.88 | 0.95 |
OPU ovum pickup, ET embryo transfer, SET single embryo transfer, LBR live-birth rate