Table 3.
Comparison of IVF/ICSI treatment cycle outcomes between women with present ovarian endometrioma versus controls
| Women with ovarian endometrioma (treatments n = 115) | Control women (treatments n = 4301) | p value | p value (adjusted for IVF/ICSI and agonist/antagonist) | |
|---|---|---|---|---|
| Days of gonadotropin stimulation | 10.84 (10.55–11.13) | 10.47 (10.40–10.53) | 0.0164 | 0.93 |
| FSH total dose (IU)/OPU | 3081 (2815–3347) | 2370 (2328–2412) | < 0.0001 | 0.0316 |
| Oocytes (total number retrieved at OPU) | 7.64 (6.67–8.61) | 9.54 (9.37–9.71) | 0.0009 | 0.0055 |
| Ovarian sensitivity index | 3.60 (2.94–4.26) | 5.74 (5.59–5.90) | < 0.0001 | 0.0005 |
| Embryos obtained | 4.10 (3.43–4.78) | 4.32 (4.19–4.46) | 0.54 | 0.13 |
| Embryoscore (1–10) day 2 | 9.51 (9.26–9.75) | 9.41 (9.36–9.46) | 0.42 | 0.48 |
| Frozen embryos | 1.86 (1.45–2.26) | 2.51 (2.42–2.61) | 0.0044 | 0.0042 |
| Embryos to ET (fresh) | 1.29 (1.20–1.38) | 1.24 (1.23–1.26) | 0.28 | 0.48 |
| Embryos to ET (thaw) | 1.11 (1.02–1.19) | 1.08 (1.07–1.10) | 0.60 | 0.48 |
| SET (%) | 70.59 (61.59–79.58) | 75.62 (74.22–77.03) | 0.26 | 0.44 |
| Canceled cycles (No OPU or no ET) (%) | 11.30 (5.43–17.18) | 16.23 (15.13–17.33) | 0.18 | 0.23 |
| Clinical pregnancy/stimulation start (%) | 30.43 (21.90–38.97) | 28.95 (27.59–30.30) | 0.73 | 0.97 |
| Clinical pregnancy/OPU (%) | 31.25 (22.53–39.97) | 31.06 (29.62–32.49) | 0.97 | 0.97 |
| Clinical pregnancy/ET (%) | 34.31 (24.94–43.68) | 34.55 (33.00–36.11) | 0.96 | 0.84 |
| Clinical pregnancy/ET thaws (%) | 32.14 (19.52–44.76) | 31.59 (29.52–33.67) | 0.94 | – |
| Cumulative clinical pregnancy/OPU (fresh and frozen ET) (%) | 46.43 (37.05–55.81) | 40.41 (38.89–41.93) | 0.22 | 0.21 |
| Cumulative clinical pregnancy/ET (fresh and frozen ET) (%) | 50.98 (41.11–60.85) | 44.24 (42.62–45.86) | 0.19 | 0.27 |
| Live-birth rates (LBRs)/stimulation start (%) | 24.35 (16.38–32.31) | 23.79 (22.51–25.06) | 0.89 | 0.94 |
| LBRs/OPU (%) | 25.00 (16.86–33.14) | 25.52 (24.17–26.87) | 0.90 | 0.94 |
| LBRs/ET (%) | 27.45 (18.64–36.26) | 28.39 (26.92–29.87) | 0.84 | 0.78 |
| LBRs/ET thaws (%) | 25.00 (13.30–36.70) | 26.16 (24.20–28.12) | 0.86 | – |
| Cumulative LBRs/OPU (fresh and frozen ET) (%) | 38.39 (29.25–47.54) | 34.67 (33.20–36.15) | 0.41 | 0.39 |
| Cumulative live-birth/ET (fresh and frozen ET) (%) | 42.16 (32.41–51.90) | 37.89 (36.30–39.47) | 0.38 | 0.46 |
| Miscarriages (%) | 20.00 (6.06–33.94) | 17.83 (15.70–19.96) | 0.75 | 0.83 |
Data are mean or percent (95% CI). OPU = ovum pickup, ET = embryo transfer, SET = single embryo transfer, LBR = Live-birth rate