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. 2019 Mar 28;8(9):945–958. doi: 10.1002/sctm.18-0246

Figure 5.

Figure 5

Genes with consistent expression differences between early and presenescent human umbilical cord perivascular cells (HUCPVCs) have multifarious functions. (A): Venn diagram of significantly differentially expressed (DE) probe sets (q < .05) with >2‐fold difference between P2 and P10, P11 and P12. Fifty two probe sets, corresponding to 43 genes, are common to the three presenescent passages. Twenty‐one thousand six hundred sixty five probe sets did not meet this criterion. (B): Expression intensity of the 52 commonly DE probe sets identified in (A) represented by heat map. Probe sets are segregated by those with decreased (top) and increased (bottom) expression intensity versus P2, clustered based on Pearson correlation. All passages analyzed, beginning at P2 through senescence, are represented. Expression trends are highly consistent between all HUCPVC donor populations, including the technical replicates F2 and F2.2. Abbreviations: F, female; M, male; P, passage.