Figure 5.

Extracellular vesicles/exosomes (EV/Exs) upregulate phosphorylation of various kinases in endothelial cells: a human phosphor‐kinase array was used to determine kinase phosphorylation in HUVEC upon their exposure to EV/Exs or medium alone (med) for indicated time. (A): Heatmap presenting quantification of signals from array as pixel intensities normalized to control signals. (B): Histograms presenting the seven more pronounced kinase activation induced by EV/Exs as fold increase, compared with medium, in pixel intensities (signals) from array at 1, 4, and 8 hours of treatment. Results are presented as mean values ± SD of duplicates.