Table 4.

Histopathological healing score analysis for bone regeneration four weeks post-operation period (osteoblasts, osteoclast cells, bone formation, blood vessels).

Score	New bone formation D1/control	New bone formation D2/Osteon II Collagen with HA	Mann–Whitney test
	Frequency	Frequency
0	0	0	U = 0.000
1	1	0	Z = 2.835
2	4	0
3	0	5
Total	5	5	P-value = 0.008*
D1 vs D3 U = 3.000, Z = −2.154, P = 0.056 D1 vs D4 U = 12.500, Z = 0.000, P = 1.000 D2 vs D3 U = 7.500, Z = −1.500, P = 0.310 D2 vs D4 U = 0.000, Z = −2.835, P = 0.008* D3 vs D4 U = 3.000, Z = −2.154, P = 0.056
Score	Osteoblast cells D1/Control	Osteoblast cells D2/Osteon II Collagen with HA	Mann–Whitney test
0	0	0	U = 2.000
1	1	0	Z = −2.425
2	4	1
3	0	4
Total	5	5	P-value = 0.015*
D1 vs D3 U = 4.000, Z = −2.032, P = 0.042* D1 vs D4 U = 9.500, Z = −0.693, P = 0.488 D2 vs D3 U = 10.000, Z = −0.655, P = 0.513 D2 vs D4 U = 3.500, Z = −2.041, P = 0.041* D3 vs D4 U = 4.500, Z = −0.771, P = 0.077
Kruskal–Wallis test – osteoclast cells		Chi-square = 4.328	P-value = 0.228
Kruskal–Wallis test – blood vessels		Chi-square = 3.000	P-value = 0.392