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Summary of variant classification in COSMIC and VIC
| VIC | COSMIC | Total | ||
|---|---|---|---|---|
| Pathogenic | Neutral | None* | ||
| Strong significance | 6 | 0 | 0 | 6 (0.00%) |
| Potential significance | 14,783 | 416 | 567 | 15,766 (5.78%) |
| Uncertain significance | 158,353 | 50,026 | 48,363 | 256,742 (94.20%) |
| Benign/likely benign | 8 | 33 | 5 | 46 (0.02%) |
| Total | 173,150 (63.53%) | 50,475 (18.52%) | 48,935 (17.95%) | 272,560 |
*COSMIC variants without “FATHMM_prediction” records in the database
