Table 2.
Summary details of two LBC cohorts and the relationship between all-cause mortality and predicted age from different methods (before and after cell count correction)
| LBC1921 wave one | LBC1936 wave one | |
|---|---|---|
| N | 436 | 906 |
| N deaths | 386 | 214 |
| Chronological age, mean (SD)1 | 79.1 (0.6) | 69.5 (0.8) |
| Before cell count correction | ||
| Hannum, mean (SD) | 80.3 (6.2) | 71.3 (5.7) |
| Hannum, hazard ratio (P value, 95% CI)2 | 1.12 (0.016, 1.02–1.23) | 1.18 (0.020, 1.02–1.37) |
| Horvath, mean (SD) | 73.8 (6.9) | 66.1 (6.4) |
| Horvath, hazard ratio (P value, 95% CI) | 1.09 (0.038, 1.00–1.20) | 1.19 (0.0022, 1.06–1.32) |
| Elastic Net, mean (SD)3 | 77.4 (3.6) | 72.5 (3.2) |
| Elastic Net, hazard ratio (P value, 95% CI) | 1.08 (0.38, 0.91–1.27) | 1.00 (0.96, 0.79–1.28) |
| BLUP, mean (SD)3 | 77.3 (3.3) | 72.5 (2.8) |
| BLUP, hazard ratio (P value, 95% CI) | 1.20 (0.066, 0.99–1.46) | 1.25 (0.12, 0.95–1.64) |
| After cell count correction | ||
| Hannum, hazard ratio (P value, 95% CI) | 1.10 (0.057, 1.00–1.21) | 1.11 (0.15, 0.96–1.29) |
| Horvath, hazard ratio (P value, 95% CI) | 1.07 (0.13, 0.98–1.17) | 1.14 (0.032, 1.01–1.28) |
| Elastic Net, hazard ratio (P value, 95% CI)3 | 1.07 (0.39, 0.91–1.27) | 1.03 (0.79, 0.82–1.31) |
| BLUP, hazard ratio (P value, 95% CI)3 | 1.21 (0.05, 1.00–1.48) | 1.21 (0.17, 0.92–1.60) |
1Mean (predicted) age and its standard deviation
2Hazard ratio, P value, and 95% confidence interval from the survival analysis based on the predicted age. Hazard ratios were expressed per 5 years of methylation age acceleration
3Both results of Elastic Net and BLUP were based on the age predictor with the largest training sample size (sample size = 10,411 for LBC1936 and sample size = 12,710 for LBC1921)