Table 3.

Univariate and Multivariate Analysis by a Cox Proportional Hazards Regression Model in Cohort

Variable	OS
	Univariate		Multivariate
	HR (95% CI)	P Value	HR (95% CI)	P Value
Age, years (>  45 vs. ≤ 45)	0.898 (0.581–1.390)	0.630	NA
ER (positive vs. negative)	1.114 (0.711–1.745)	0.637	NA
PR (positive vs. negative)	1.213 (0.775–1.899)	0.398	NA
CrebB-2 (positive vs. negative)	1.128 (0.705–1.806)	0.615	NA
Menstrual history (presence vs. absence)	1.381 (0.851–2.241)	0.191	NA
Operation		0.649	NA
Modified radical mastectomy vs. radical correction	1.150 (0.727–1.820)	0.550	NA
Other operation vs. radical correction	0.642 (0.155–2.663)	0.542	NA
FADD (positive vs. negative)	1.580 (0.995–2.509)	0.053	NA
NDRG1 (low vs. high)	1.302 (0.762–2.226)	0.335	NA
CRYAB (positive vs. negative)	1.561 (0.902–2.701)	0.112	NA
Tumor diameter, cm		0.072		NS
> 5 vs. > 2 and ≤ 5	1.923 (1.019–3.636)	0.043
> 5 vs. ≤2	2.230 (1.093–4.549)	0.027
TNM stage		< 0.0001		NS
III vs. I	4.329 (1.824–10.273)	0.001
III vs. II	2.101 (1.333–3.311)	0.001
Histology stage (poorly differentiation vs. high-middle differentiation)	2.286 (1.100–4.751)	0.027		NS
Histology type (lobular carcinoma vs. duct carcinoma)	1.720 (1.025–2.886)	0.040	1.846 (1.093–3.118)	0.022
Lymph node metastasis (presence vs. absence)	2.810 (1.694–4.662)	< 0.0001	2.801 (1.688–4.649)	< 0.0001
EpCAM (positive vs. negative)	2.306 (1.218–4.367)	0.010	2.585 (1.351–4.944)	0.004

Data in bold are P values < 0.05