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. 2019 Aug 23;20:58. doi: 10.1186/s12910-019-0395-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The schema of NCI-MATCH study design. The biopsy material derived from registered patients is characterized for specific pre-defined mutations via genetic sequencing. If an actionable mutation is detected, patients are assigned to 1 of 30 treatment sub-protocols. Those experiencing disease progression or serious adverse events undergo review of their previous biopsy results or undergo another biopsy to search for alternative treatment [10]