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. 2019 Aug 23;17:106. doi: 10.1186/s12964-019-0413-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — 9F7-F11 induces downregulation of the pro-survival proteins c-IAP2 and XIAP. Cells were incubated with 9F7-F11, before western blot analysis of cIAP2 and XIAP (survival factors) and of UP9X (deubiquitinase) expression in protein lysates prepared at different time points. Quantification of signal intensity (SI) with ImageJ software is indicated below the images (relative to untreated control measured as 1.0 ± .0). Significant increase or decrease of the densitometry, compared to control, is indicated in bold. β-tubulin was evaluated as loading control