FIG. 2.

CypD activation by S-glutathionylation and acetylation promotes mitochondrial impairment and oxidative stress, which contribute to vascular dysfunction and hypertension, and CypD depletion or CypD inhibition improves vascular function and diminishes hypertension. CypD, cyclophilin D; H₂O₂, hydrogen peroxide; mPTP, mitochondrial permeability transition pore. Color images are available online.