FIG. 6.
NOS contributes to oxidant production in cells from obese asthmatic subjects. (A, B) Total cellular H2O2 production measured in the absence (black bars) and presence (white bars) of L-NAME (100 μM) in (A) airway epithelial cells and (B) platelets. (C) The 3-nitrotyrosine concentration measured in epithelial cells (black bars) and platelets (white bars) from healthy lean, asthmatic lean, healthy obese, and asthmatic obese individuals. n = 5 in each group. Data are mean ± SEM. Statistical significance determined by one-way ANOVA. #p < 0.05 and *p < 0.01. L-NAME, L-NG-nitroarginine methyl ester.