Table 1.

Details of Cat Subretinal Implantation

Animal (Cat)	Age	Sex	Eye	Result of surgical transplantation	SD-OCT findings	Duration	Immuno suppression	Notes
Subject 1	5.7 years	F	OD	Unsuccessful	—	28 days	Prednisolone only
			OS	5 organoids implanted subretinally	Organoids remained separate. Some disruption of overlying retinal lamination.			Poor survival, medium-size graft, massive number of Iba1[+] cells
Subject 2	5.7 years	F	OD	5 organoids implanted subretinally	Organoids present in subretinal space. Lamination of overlying retina preserved	66 days	Prednisolone only	Poor survival, large graft, patches of surviving HNu[+] cells remaining, massive number of Iba1[+] cells
			OS	5 organoids implanted subretinally	Organoids present in subretinal space. Lamination of overlying retina preserved			Poor survival, very small patch of HNu[+] cells remaining
Subject 3	7.4 years	F	OD	Unsuccessful	—	36 days	Cyclosporine A and prednisolone
			OS	8 organoids implanted subretinally	Organoids appeared to coalesce into one structure. Some disruption of overlying retinal lamination.			Good survival of human graft
Subject 4	6 years	M	OD	6 organoids implanted subretinally	Organoids appeared to coalesce into one structure. Some disruption of overlying retinal lamination	36 days	Cyclosporine A and prednisolone	Good survival of human graft
			OS	9 organoids implanted subretinally	Organoids appeared to coalesce into one structure. Some disruption of overlying retinal lamination.			Cellular infiltration in peripheral residual vitreous graft did not survive
Subject 5	6 years	F	OD	Unsuccessful	—	36 days	Cyclosporine A and prednisolone
			OS	8 organoids implanted subretinally	Organoids appeared to coalesce into one structure. Some disruption of overlying retinal lamination.			Good survival of human graft

OS, left eye; OD, right eye.