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. Author manuscript; available in PMC: 2019 Aug 24.
Published in final edited form as: Lancet Digit Health. 2019 Jun 27;1(3):e136–e147. doi: 10.1016/S2589-7500(19)30058-5

Figure 3.

Figure 3.

Ameliorating treatment failure by adjusting the radiation dose. (a) Heatmap demonstrating the relationship between Deep Profiler score (x-axis), iGray in biologically effective dose (BED) units (y-axis) and the probability of local failure (right legend). As iGray dose increases, the risk of failure decreases and vice versa. (b) The kernel density estimation of the actual dose of radiation delivered and iGray. (c) Violin plots of the distribution for the percent change in dose delivered required to achieve iGray stratified by the four treatment categories (y-axis). (d) The probability of local failure was calculated for patients receiving the most common treatment regimen of 100 Gy BED after incremental increases in radiation dose. The overall rate of local failure is significantly diminished at the highest doses. (e) A depiction of the proximal bronchial tree (PBT). A proposed theoretical dose scheme to avoid proximal airway toxicity is shown in the bottom (see Methods). (f) The cumulative relative frequency of feasibly delivering iGray per the scheme in (e). Some iGray doses are shown (arrows) to highlight the range in which a substantial decrement in feasibility occurs.