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. Author manuscript; available in PMC: 2020 Mar 8.
Published in final edited form as: Science. 2019 Mar 8;363(6431):eaat4042. doi: 10.1126/science.aat4042

Fig 3. SFB antigens are shuttled through the IEC endosomal-lysosomal vesicular network.

Fig 3.

(A, B) Immunofluorescence for P3340 on intestinal sections from terminal ileum showing SFB P3340 inside IECs (yellow arrowheads). (C, D) P3340 is present in EEA1+ early endosomes. White dashed line outlines the apical IEC surface. (E-H) Co-localization of intracellular SFB protein P3400 (red) with endosomal and lysosomal markers (green). P3340 co-localizes with late endosomes (LBPA, Rab7) (E, F), as well as basolateral lysosomes (LAMP2) (G). (H) Some P3340 also co-localizes with recycling endosomes (Rab11).