Fig. 1.

(A–E) Effect of varying forces (6 to 45 pN) on half-life of agonist TCR–pMHC bonds. Half-lives of bonds calculated from off-rate measured between 0 and 5 s (Left) are plotted versus force (Bottom). Error bars are experimental SEM. (F) Schematics illustrating examples of typical slip bonds (green) and catch bonds (blue).