Fig. 1.

Odds ratios for MS with different combinations of risk factors. Risk factors include ANO2 seropositivity, DRB1*15:01 carrier, A*02:01 noncarrier, and EBNA1-high (anti-EBNA1 antibody levels above median in controls). Red box indicates that the group of individuals is exposed to the risk factor and white box that they are not. The ORs were calculated by comparison with a reference group, carrying none of the risk factors. Total numbers of MS cases and controls in each group and P values are presented in SI Appendix, Table S3. Bars in the graph indicate 95% confidence intervals.