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. 2019 Aug 1;116(34):17007–17012. doi: 10.1073/pnas.1908072116

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Fig. 2. — NTCP usage and zoonotic potential of shrew HBVs. (A) NTCP/Ntcp-preS1 binding sites. Arrows, sites under positive selection for primates (gray), rodents (blue) (27), and Eulipotyphla (red). Yellow background, shrew HBV hosts. (B) Taurocholate (NBD-TC) uptake (green) by Sorex Ntcp. Blue, nuclei. (C) Myristoylated preS1 peptide binding (red) to human or Sorex NTCP/Ntcp. (D) Infection of HDV pseudotypes via human or Sorex NTCP/Ntcp. Red, newly produced Delta antigen. Blue, nuclei. (E) Inhibition of CSHBV Gt A replication. ETV, Entecavir. (F) Infection of primary human/tupaia hepatocytes by HDV pseudotypes. d.p.t, days posttransfection; GE, genome equivalents; Gt, genotype.