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. 2019 Aug 5;116(34):16981–16986. doi: 10.1073/pnas.1905239116

Fig. 4.

Fig. 4.

Suppression of FYN is indispensable for dasatinib activity. Dose–response curves to dasatinib for HBL1 (A, C, E, G) and WSU-NHL (B, D, F, H) cells engineered to express BLK, FYN, or LYN either WT or GK in each of the possible 8 combinations (***P < 0.001; t test). For each combination, the indicated gatekeeper cDNA(s) was cotransduced with the remaining WT kinase(s). Error bars represent SDs (n = 4 replicates per dose–response point). Statistical significance is shown for the indicated concentrations and gatekeeper combination vs. the ALL WT combination.