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. 2019 Aug 20;13:2923–2931. doi: 10.2147/DDDT.S216156

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© 2019 Han et al.

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Rut inhibits the apoptosis of nerve cells in MCAO rats. The rats were grouped into five groups (ten in each group): control group, the rats were received similar surgical treatment but no screws were inserted; CI/R model; CI/R+Rut (5 mg/kg), the CI/R rats were treated with 5 mg/kg for 4 weeks; CI/R+Rut (10 mg/kg), the CI/R rats were treated with 10 mg/kg for 4 weeks; CI/R+Rut (20 mg/kg), the CI/R rats were treated with 20 mg/kg for 4 weeks. (A) Apoptotic cells were measured by TUNEL staining. (B) The mRNA and protein levels of caspase 3 were measured by RT-qPCR and Western blotting. (C) The protein levels of Bcl-2 and Bax were measured by Western blotting. GAPDH was used as the internal reference. (*p<0.05 vs control group; #p<0.05 vs CI/R group).

Abbreviations: CI/R, cerebral ischemia-reperfusion; Rut, rutaecarpine; MCAO, middle cerebral artery occlusion; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.