. Author manuscript; available in PMC: 2020 Jun 10.

Published in final edited form as: J Control Release. 2019 Apr 11;303:109–116. doi: 10.1016/j.jconrel.2019.04.013

Table 1.

Plasma pharmacokinetic parameters of paclitaxel after single IV administration of Taxol® and L-PTX formulations to rats (n=4)

PK Parameters	t_1/2	C₀	AUC_last	V_ss	CL_T	MRT
PK Parameters	h	ng/mL	ng*h/mL	mL/kg	mL/h/kg	h
Taxol®	1.06	9126	7872	857	721	0.94
L-PTX	0.33	2599	1275	2283	4630	0.46

AUC_last, area under the curve to the last measurable concentration; C₀, concentration at time 0 h; CL_T, total body clearance; MRT, mean residence time; t_1/2, half-life; V_ss, volume of distribution at steady state.