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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Exp Neurol. 2019 Jun 7;320:112975. doi: 10.1016/j.expneurol.2019.112975

Figure 2. Noradrenergic or serotonergic depletion prevent VNS-directed cortical plasticity.

Figure 2

(A) Total area of proximal forelimb presentation for each experimental group. VNS paired with lever training more than doubles proximal forelimb representation of vehicle injected rats compared to rats that underwent equivalent lever training without VNS. Noradrenergic or serotonergic depletion prevent this VNS-dependent expansion. (B) Bubble plots indicating the percentage of rats with a proximal forelimb response at each location in motor cortex. Note the increase in cortical representation of proximal forelimb representation throughout motor cortex in rats that received VNS paired with training. * denotes Bonferroni-corrected p < 8.3 × 10−3 compared to VNS-control.