Effects of RvD1 on neurological function and brain tissue loss at 4 weeks post hypoxia-ischemia (HI). Compared with vehicle, RvD1 treatment group alleviated long term neurological deficits, including foot fault test (A), rotarod test (B), swimming distance to find the platform (C), escape latency (D) and time spent in the target quadrant (E). (F) Representative pictures of swim track in Probe Trial. (G) Representative pictures of Nissl’s stained brain slices and schematic diagram (H) showed that RvD1 treatment significantly reduced the percent of tissue loss when compared with vehicle. ANOVA followed by Tukey test was used for analysis. Data were shown as mean ± SD (n=12 per group). * P < 0.05 vs. sham; # P < 0.05 vs. HI+vehicle. RvD1, resolvin D1.