Table 5.
Rate per l,000a (and frequency) of indicated PTB: overall and by indication.
| Women without autoimmune disease (n = 204,384) | Type I Diabetes (n = 507) | Systemic Lupus Erythematosus (n = 202) | Crohn’s Disease (n = 169) | Multiple Sclerosis (n = 146) | Rheumatoid Arthritis (n = 123) | |
|---|---|---|---|---|---|---|
| Indicated Preterm Delivery | 17.8 (3650) | 145.9 (74)* | 103.9 (21)* | 29.5 (5)* | 27.3 (4) | 16.2 (2) |
| Preeclampsia (all) | 6.59 (1348) | 47.33 (24)* | 29.70 (6)* | 17.75 (3) | 6.84 (1) | 0 (0) |
| Maternal Conditionb | 4.95 (1012) | 43.39 (22)* | 49.50 (10)b | 17.75 (3)* | 6.84 (1) | 0 (0) |
| Admission for maternal reason | 2.98 (611) | 27.61 (14)* | 14.85 (3) | 11.83 (2) | 0 (0) | 0 (0) |
| History of pregnancy conditionc | 2.89 (592) | 27.61 (14)* | 24.75 (5) | 5.91 (1) | 6.84 (1) | 8.13 (1) |
| Fetal anomaly | 2.64 (540) | 27.61 (14)* | 24.75 (5)* | 0 (0) | 0 (0) | 8.13 (1) |
| Fetal conditiond | 2.16 (443) | 7.88 (4) | 14.85 (3)* | 0 (0) | 0 (0) | 0 (0) |
| Gestational diabetes | 1.89 (388) | 0 (0) | 4.95 (1) | 11.83 (2) | 13.69 (2) | 8.13 (1) |
| Superimposed Preeclampsia | 1.68 (345) | 23.66 (12)* | 4.95 (1)* | 5.91 (1) | 6.84 (1) | 0 (0) |
| Stillbirth | 1.51 (310) | 3.94 (2) | 4.95 (1) | 0 (0) | 0 (0) | 0 (0) |
| Pregestational diabetes | 1.25 (256) | 145.9 (74) | 9.90 (2) | 5.91 (1) | 0 (0) | 0 (0) |
| Gestational Hypertension | 1.23 (252) | 11.83 (6) | 9.90 (2) | 0 (0) | 0 (0) | 0 (0) |
| Maternal Fever | 1.15 (237) | 7.88 (4) | 4.95 (1) | 0 (0) | 0 (0) | 0 (0) |
| Admission for fetal reasone | 1.12 (229) | 3.94 (2) | 4.95 (1) | 0 (0) | 0 (0) | 0 (0) |
| Chronic hypertension | 0.94 (194) | 15.77 (8)* | 9.90 (2) | 0 (0) | 0 (0) | 8.13 (1) |
| Abruption | 0.81 (167) | 1.97 (1) | 9.90 (2) | 0 (0) | 0 (0) | 0 (0) |
| Prior uterine scar | 0.67 (138) | 1.97 (1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Unspecified HTN | 0.27 (57) | 1.97 (1)* | 0 (0) | 0 (0) | 6.84 (1) | 0 (0) |
| Chorioamnionitis | 0.25 (53) | 1.97 (1) | 4.95 (1)* | 0 (0) | 0 (0) | 0 (0) |
| Fetal macrosomia | 0.20 (42) | 1.97 (1)* | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Vaginal bleeding | 0.20 (41) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Previa | 0.13 (28) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Eclampsia | 0.12 (26) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
*
p < 0.05 Indicates rate among women with autoimmune disease different than rate among women without autoimmune disease.
a
Categories for the indicated precursors are not mutually exclusive as multiple obstetric or fetal conditions were included in the same pregnancy.
b
Maternal conditions included maternal medical problems such as cardiac or renal disease.
c
History of maternal or fetal condition included pregnancy complications in a previous pregnancy only.
d
Fetal conditions included intrauterine growth restriction and abnormal antenatal testing.
e
Admission for fetal or maternal reason was included only if there was no other pregnancy condition.