Figure 5.

Effects of R-47 on Nicotine Reward in the Conditioned Place Paradigm. Mice were conditioned with either subcutaneous (s.c.) saline or nicotine (0.5mg/kg) for 3 days. Distilled water or R-47 (1, and 10 mg/kg; p.o) pretreatment were given 120-min prior to nicotine-conditioning. Nicotine itself induces a robust place preference but R-47 pretreatment doesn’t block the effect of nicotine. * Denotes p<0.05 from vehicle control. Each point represents the mean ± SEM of n=10–12 mice per group.