Figure 9.

R-47 does not enhance A549 NSCLC tumor growth alone or in combination with paclitaxel in NSG mice. Mice were subcutaneously injected with 1.5 × 106 cells in each flank. Once tumors became palpable, mice were given R-47 (10 mg/kg, p.o.) twice daily for 3 days starting on Day 1, then once daily in combination with paclitaxel (10 mg/kg, i.p.) for 4 days starting on Day 4. A) The left and right flank tumor volumes (l × w × h) were determined with calipers and values were averaged for each mouse. Data are expressed as mean + SEM; n = 8–9 mice per group. *P < 0.05, ***P < 0.001 vs Veh-Water. B) Mice were euthanized on day 17, after which tumors were extracted and weighed; tumor weights were averaged for each mouse. *P < 0.05, **P < 0.01 vs Veh-Water. Data are expressed as mean + SEM; n = 8–9 mice per group. Veh, vehicle; Pac, paclitaxel.