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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Ocul Surf. 2019 Jun 5;17(3):374–383. doi: 10.1016/j.jtos.2019.06.001

Figure 2. TSP-1 regulates TGF-β1-mediated modulation of the immune response.

Figure 2

TSP-1 promotes the activation of TGF-β1, which is required for the development of Foxp3+ Tregs, which suppress the pro-inflammatory response. TGFβ also limits the activity of NK cells, B cells, Th1 and Th2 cells thereby suppressing the immune response. However, in combination with IL-6, TGF-β1 supports the development of Th17 cells; pro-inflammatory cells that have been shown to play a critical role in the pathogenesis of various autoimmune inflammatory diseases.