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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Exp Neurol. 2019 May 28;320:112967. doi: 10.1016/j.expneurol.2019.112967

Table 3.

TLR2/4 DEGs across human and murine tissue

Significant
Human
DEGs		 Number of
Mouse Models
with Significant
DEGs		 Direction of
Human
Dysregulation		 Direction of Mouse Dysregulation
Diabetic
vs
control		 Changes
over time		 Diabetic in
response to
treatment
AKT2 3 ↓ ↓ ↑
CASP8 3 ↓ ↑ ↑ ↑
CD86 3 ↑ ↑ ↓
CXCL9 3 ↓ ↔ ↑
IFNAR1 2 ↑ ↓
IFNAR2 1 ↓ ↑
IRF5 3 ↓ ↑
JUN 1 ↑ ↓
LBP 6 ↓ ↑ ↓ ↓
MAP2K1 1 ↓ ↑
MAP2K7 2 ↑ ↑ ↓
MAP3K8 2 ↓ ↑
MAPK1 1 ↑ ↓
MAPK10 2 ↓ ↓ ↓
PIK3CB 4 ↓ ↑ ↑
PIK3R2 3 ↑ ↓ ↓ ↓
PIK3R3 3 ↓ ↑ ↑
STAT1 1 ↓ ↓
TAB2 1 ↑ ↓
TICAM1 1 ↑ ↓

Significantly dysregulated genes in both human and murine neuropathy and their directionality. Cells highlighted in blue represent downregulated gene expression, red represent upregulated gene expression, and purple represent mixed directionality of gene expression. Cells highlighted in green in the ‘Significant Human DEGs’ column represent significantly dysregulated genes using both ChipInspector and ChipInspector + GenePattern analysis platforms in the human data, and cells highlighted in green in the ‘Number of Mouse Models with Significant DEGs’ column represent significantly dysregulated genes across both human analysis platforms and across 4 or more mouse models.