Table 3.
Significant Human DEGs |
Number of Mouse Models with Significant DEGs |
Direction of Human Dysregulation |
Direction of Mouse Dysregulation | ||
---|---|---|---|---|---|
Diabetic vs control |
Changes over time |
Diabetic in response to treatment |
|||
AKT2 | 3 | ↓ | ↓ | ↑ | |
CASP8 | 3 | ↓ | ↑ | ↑ | ↑ |
CD86 | 3 | ↑ | ↑ | ↓ | |
CXCL9 | 3 | ↓ | ↔ | ↑ | |
IFNAR1 | 2 | ↑ | ↓ | ||
IFNAR2 | 1 | ↓ | ↑ | ||
IRF5 | 3 | ↓ | ↑ | ||
JUN | 1 | ↑ | ↓ | ||
LBP | 6 | ↓ | ↑ | ↓ | ↓ |
MAP2K1 | 1 | ↓ | ↑ | ||
MAP2K7 | 2 | ↑ | ↑ | ↓ | |
MAP3K8 | 2 | ↓ | ↑ | ||
MAPK1 | 1 | ↑ | ↓ | ||
MAPK10 | 2 | ↓ | ↓ | ↓ | |
PIK3CB | 4 | ↓ | ↑ | ↑ | |
PIK3R2 | 3 | ↑ | ↓ | ↓ | ↓ |
PIK3R3 | 3 | ↓ | ↑ | ↑ | |
STAT1 | 1 | ↓ | ↓ | ||
TAB2 | 1 | ↑ | ↓ | ||
TICAM1 | 1 | ↑ | ↓ |
Significantly dysregulated genes in both human and murine neuropathy and their directionality. Cells highlighted in blue represent downregulated gene expression, red represent upregulated gene expression, and purple represent mixed directionality of gene expression. Cells highlighted in green in the ‘Significant Human DEGs’ column represent significantly dysregulated genes using both ChipInspector and ChipInspector + GenePattern analysis platforms in the human data, and cells highlighted in green in the ‘Number of Mouse Models with Significant DEGs’ column represent significantly dysregulated genes across both human analysis platforms and across 4 or more mouse models.