Table 2.

Prognostic significance (cancer-related survival) of clinicopathological parameters using the Cox’s regression model

Parameter	N	Cancer-related survival
		Relative risk	95% confidence interval	p value
Univariate analysis
pT category	105	12.3	1.7–90.3	0.013*
pN category	105	5.5	2.5–11.8	< 0.001***
M category	105	18.8	8.4–42.1	< 0.001***
EZH2 score 30	105	0.4	0.2–0.9	0.027*
EZH2 differencea	105	2.1	1.0–4.2	0.042*
Tumor grading	105	1.3	0.7–2.7	0.403
Sex	105	0.5	0.2–1.0	0.064
Age (66 cutoff)	105	1.3	0.6–2.5	0.488
Localizationb	105	1.3	0.7–2.6	0.438
MMRP loss	105	1.0	0.4–2.2	0.948
Tumor buddingc	105	2.5	1.2–5.3	0.016*
Multivariate analysis
pT category	105	4.2	0.5–33.3	0.173
pN category	105	2.1	0.9–5.2	0.091
M category	105	12.3	4.8–31.6	< 0.001***
EZH2 score 30	105	1.6	0.6–3.9	0.318
EZH2 differencea	105	2.8	1.3–6.2	0.012*
Tumor buddingc	105	1.4	0.6–3.4	0.404

*p < 0.05, ***p < 0.001

^aEZH2 score (Δtumor center–tumor invasion front)

^bProximal versus distal

^cLow/intermediate versus high