Table 2:

The results of meta-analysis for association of MMP-9 -1562C>T polymorphism with periodontitis risk

Polymorphism	Genetic Model	Type of Model	Heterogeneity		Odds Ratio				Publication Bias
			I2(%)	PH	OR	95% CI	Ztest	POR	PBeggs	PEggers
Overall	T vs. C	Random	94.15	≤0.001	0.787	0.459–1.348	−0.872	0.383	0.854	0.033
	TC vs. CC	Random	78.19	≤0.001	0.795	0.546–1.156	−1.202	0.229	0.427	0.180
	TT vs. CC	Random	86.17	≤0.001	0.600	0.237–1.517	−1.080	0.280	0.854	0.156
	TT+TC vs. CC	Random	89.69	≤0.001	0.767	0.463–1.269	−1.034	0.301	0.582	0.050
	TT vs. TC+CC	Random	79.48	≤0.001	0.691	0.330–1.444	−0.983	0.326	0.854	0.206
Periodontitis Type
CP	T vs. C	Random	94.45	≤0.001	0.611	0.321–1.163	−1.500	0.134	0.754	0.140
	TC vs. CC	Random	81.95	≤0.001	0.676	0.416–1.101	−1.573	0.116	0.465	0.326
	TT vs. CC	Random	82.78	≤0.001	0.375	0.146–0.964	−2.036	0.042	0.916	0.357
	TT+TC vs. CC	Random	90.85	≤0.001	0.607	0.324–1.137	−1.558	0.119	0.602	0.175
	TT vs. TC+CC	Random	71.17	0.001	0.473	0.235–0.954	−2.092	0.036	1.000	0.452
AgP	T vs. C	Random	74.32	0.009	1.373	0.812–2.320	1.183	0.237	1.000	0.405
	TC vs. CC	Fixed	0.00	0.716	1.112	0.806–1.534	0.644	0.519	0.308	0.283
	TT vs. CC	Random	63.47	0.042	1.849	0.407–8.396	0.796	0.426	0.734	0.307
	TT+TC vs. CC	Fixed	41.65	0.162	1.199	0.880–1.632	1.151	0.250	0.308	0.238
	TT vs. TC+CC	Fixed	60.89	0.053	2.585	1.177–5.678	2.367	0.018	0.734	0.327
By ethnicity
Caucasian	T vs. C	Fixed	48.15	0.122	0.723	0.572–0.914	−2.717	0.007	0.089	0.013
	TC vs. CC	Fixed	36.74	0.192	0.753	0.568–1.000	−1.962	0.050	0.089	0.044
	TT vs. CC	Fixed	0.00	0.594	0.347	0.133–0.909	−2.155	0.031	0.308	0.058
	TT+TC vs. CC	Fixed	46.13	0.135	0.709	0.538–0.936	−2.429	0.015	0.089	0.015
	TT vs. TC+CC	Fixed	0.00	0.640	0.378	0.145–0.983	−1.994	0.046	0.308	0.107
Asian	T vs. C	Random	96.84	≤0.001	0.856	0.345–2.121	−0.336	0.737	0.763	0.035
	TC vs. CC	Random	87.48	≤0.001	0.812	0.424–1.555	−0.628	0.530	0.367	0.073
	TT vs. CC	Random	92.92	≤0.001	1.017	0.279–3.710	0.026	0.979	0.229	0.067
	TT+TC vs. CC	Random	94.36	≤0.001	0.806	0.339–1.919	−0.487	0.626	0.367	0.015
	TT vs. TC+CC	Random	89.37	≤0.001	1.092	0.404–2.946	0.173	0.863	0.229	0.061
Mixed	T vs. C	Fixed	0.00	0.596	0.885	0.494–1.585	−0.412	0.681	NA	NA
	TC vs. CC	Fixed	0.00	0.453	1.081	0.553–2.111	0.228	0.820	NA	NA
	TT vs. CC	Fixed	0.00	0.883	0.228	0.023–2.242	−1.267	0.205	NA	NA
	TT+TC vs. CC	Fixed	0.00	0.512	0.978	0.509–1.879	−0.066	0.947	NA	NA
	TT vs. TC+CC	Fixed	0.00	0.915	0.227	0.023–2.213	−1.277	0.202	NA	NA
By HWE
	T vs. C	Random	75.10	≤0.001	1.138	0.771–1.679	0.652	0.514	0.602	0.337
	TC vs. CC	Fixed	33.17	0.152	1.067	0.848–1.342	0.554	0.579	0.916	0.921
	TT vs. CC	Random	53.28	0.029	1.366	0.570–3.273	0.699	0.485	0.175	0.026
	TT+TC vs. CC	Random	63.18	0.005	1.102	0.761–1.597	0.516	0.606	0.916	0.696
	TT vs. TC+CC	Fixed	45.56	0.065	1.873	1.123–3.125	2.402	0.016	0.175	0.028

CP: Chronic periodontitis; AgP: Aggressive periodontitis; NA: not applicable