Table 3:
The results of meta-analysis for association of MMP-2 -753C>T polymorphism with periodontitis risk
| Polymorphism | Genetic Model | Type of Model | Heterogeneity | Odds Ratio | Publication Bias | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| I2(%) | PH | OR | 95% CI | Ztest | POR | PBeggs | PEggers | |||
| Overall | T vs. C | Fixed | 17.36 | 0.301 | 0.940 | 0.780–1.132 | −0.654 | 0.513 | 1.000 | 0.832 |
| TC vs. CC | Fixed | 0.00 | 0.463 | 0.985 | 0.776–1.249 | −0.128 | 0.898 | 1.000 | 0.571 | |
| TT vs. CC | Fixed | 0.00 | 0.715 | 0.827 | 0.486–1.406 | −0.703 | 0.482 | 0.707 | 0.384 | |
| TT+TC vs. CC | Random | 64.75 | 0.014 | 0.844 | 0.574–1.242 | −0.858 | 0.391 | 0.452 | 0.212 | |
| TT vs. TC+CC | Fixed | 0.00 | 0.797 | 0.828 | 0.492–1.394 | −0.711 | 0.477 | 0.707 | 0.899 | |
| Periodontitis Type CP | T vs. C | Fixed | 9.48 | 0.331 | 0.914 | 0.706–1.182 | −0.689 | 0.491 | 0.296 | 0.192 |
| TC vs. CC | Fixed | 0.00 | 0.386 | 0.940 | 0.680–1.299 | −0.375 | 0.708 | 0.296 | 0.440 | |
| TT vs. CC | Fixed | 0.00 | 0.536 | 0.834 | 0.421–1.652 | −0.522 | 0.602 | 0.296 | 0.306 | |
| TT+TC vs. CC | Fixed | 15.62 | 0.306 | 0.931 | 0.684–1.269 | −0.451 | 0.652 | 0.296 | 0.330 | |
| TT vs. TC+CC | Fixed | 0.00 | 0.657 | 0.890 | 0.455–1.739 | −0.341 | 0.733 | 0.296 | 0.403 | |
| AgP | T vs. C | Fixed | 46.58 | 0.154 | 0.969 | 0.740–1.270 | −0.225 | 0.822 | 1.000 | 0.372 |
| TC vs. CC | Fixed | 21.62 | 0.279 | 1.040 | 0.731–1.480 | 0.219 | 0.826 | 1.000 | 0.314 | |
| TT vs. CC | Fixed | 0.00 | 0.438 | 0.816 | 0.351–1.898 | −0.472 | 0.637 | 1.000 | 0.898 | |
| TT+TC vs. CC | Random | 82.45 | 0.003 | 0.731 | 0.324–1.650 | −0.754 | 0.451 | 0.296 | 0.059 | |
| TT vs. TC+CC | Fixed | 0.00 | 0.494 | 0.741 | 0.323–1.697 | −0.709 | 0.478 | 1.000 | 0.805 | |
| By ethnicity Caucasian | T vs. C | Fixed | 0.00 | 0.587 | 1.162 | 0.890–1.516 | 1.104 | 0.269 | 1.000 | 0.551 |
| TC vs. CC | Fixed | 0.00 | 0.753 | 1.227 | 0.888–1.692 | 1.238 | 0.216 | 1.000 | 0.549 | |
| TT vs. CC | Fixed | 0.00 | 0.763 | 1.333 | 0.583–3.046 | 0.681 | 0.496 | 1.000 | 0.823 | |
| TT+TC vs. CC | Fixed | 0.00 | 0.713 | 1.233 | 0.902–1.686 | 1.311 | 0.190 | 1.000 | 0.768 | |
| TT vs. TC+CC | Fixed | 0.00 | 0.798 | 1.237 | 0.546–2.805 | 0.510 | 0.610 | 1.000 | 0.766 | |
| Asian | T vs. C | Fixed | 0.00 | 0.906 | 0.766 | 0.590–0.996 | −1.998 | 0.046 | 0.296 | 0.536 |
| TC vs. CC | Fixed | 0.00 | 0.912 | 0.759 | 0.533–1.079 | −1.537 | 0.124 | 0.296 | 0.108 | |
| TT vs. CC | Fixed | 0.00 | 0.918 | 0.590 | 0.295–1.181 | −1.489 | 0.136 | 1.000 | 0.834 | |
| TT+TC vs. CC | Fixed | 40.21 | 0.188 | 0.587 | 0.421–0.818 | −3.144 | 0.002 | 1.000 | 0.488 | |
| TT vs. TC+CC | Fixed | 0.00 | 0.836 | 0.630 | 0.320–1.237 | −1.343 | 0.179 | 0.296 | 0.274 | |
CP: Chronic periodontitis; AgP: Aggressive periodontitis.